- 2B Darren Baker (10th round, Nationals)
- RHP Andrew Hoffman (12th round, Braves)
- LHP Nathan Lavender (14th round, Mets)
- RHP Cole Ayers (16th round, Yankees)
- RHP Aaron Haase (17th round, Tigers)
- LHP Jimmy Burnette (18th round, Blue Jays)
- RHP Deylen Miley (Houston Astros)
- C Hayden Jones (Cincinnati Reds)
- LHP Garret Schoenle (Chicago White Sox)
- RHP Jacob Delabio (Houston Astros)
Signed In 2022 But Played In 2021
- RHP Trey Nordmann (Baltimore Orioles)
- SS Chase Valentine (San Diego Padres)
- RHP Drake Batcho (Seattle Mariners)
- RHP Davis Feldman (Atlantic - Lexington Legends)
- RHP Alec Thomas (Frontier - Southern Illinois Miners)
- C Duncan Hewitt (United Shore - Utica Unicorns)
- LHP Kohl Drake (11th, Rangers)
- SS Zach Denzenzo (12th, Astros)
- RHP Duncan Davitt (18th, Rays)
- LHP Eli Ankeney (20th, Mets)
- RHP Will Geerdes (San Diego Padres)
- RHP Cole Paplham (San Diego Padres)
- 2B Matt Archer (Chicago White Sox)
- RHP Colin Fields (Detroit Tigers)